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CNV1014802 hydrochloride

CAS No. 934240-31-0

CNV1014802 hydrochloride ( GSK-1014802 hydrochloride;CNV-1014802 hydrochloride;Raxatrigine hydrochloride;Vixotrigine )

Catalog No. M16677 CAS No. 934240-31-0

CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CNV1014802 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker.
  • Description
    CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo.Pain Phase 2 Clinical
  • Synonyms
    GSK-1014802 hydrochloride;CNV-1014802 hydrochloride;Raxatrigine hydrochloride;Vixotrigine
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    934240-31-0
  • Formula Weight
    350.82
  • Molecular Formula
    C18H20ClFN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    C1CC(NC1C2=CC=C(C=C2)OCC3=CC=CC=C3F)C(=O)N.Cl
  • Chemical Name
    2-Pyrrolidinecarboxamide, 5-[4-[(2-fluorophenyl)methoxy]phenyl]-, hydrochloride (1:1), (2S,5R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bagal SK, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.
2. Deuis JR, et al. Toxins (Basel). 2016 Mar 17;8(3). pii: E78.
3. Zakrzewska JM, et al. Lancet Neurol. 2017 Apr;16(4):291-300.
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